• A team of researchers from New Delhi have found an explanation for why one sibling may develop obesity faster than the other though brought up under similar home environment with almost similar diet and habits.
  • The team analysed the genetic variations in genes of over 3,500 urban school going children (11-17 years) and found certain alterations in two genes — ARID1A and KAT2B — that can delay or hasten the process of obesity development with respect to the daily habits.
  • In response to your habits (overeating, sedentary lifestyle, exercise) these genes modify the architecture of DNA and its associated protein-complex called chromatin leading to change in expression of several biomolecules responsible for obesity development.
  • Finally, a comparative analysis showed significant associations of two variants in the ARID1A gene and one variation in the KAT2B gene.
  • The ARID1A gene regulates transcription of many genes that influence metabolism while the latter has been reported to code for a protein that controls bodyweight & hyperglycemia in mice.